Selank, a synthetic analog of the immunomodulatory peptide tuftsin, has gained prominence for its potential in cognitive enhancement and anxiety management, distinguishing itself through its unique neuropsychopharmacological properties.
What is Selank?
Selank (also known as Selanc, or scientifically as L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline) is a synthetic analog of the naturally occurring peptide tuftsin, and has garnered attention for its anxiolytic effects that make it an anti-anxiety peptide. Selank was originally developed at the Institute of Pharmacology by the Russian Academy of Sciences.
Clinical studies have shown that Selank exerts a positive influence on the GABA neurotransmitter system, akin to the mechanism of action seen in benzodiazepines, yet without the unwanted side effects typically associated with these drugs.
Selank’s ability to modulate serotonin and dopamine levels further contributes to its mood-enhancing properties, making it related to the drug Semax.
Beyond its mental health applications, Selank peptide has been shown to play important roles throughout the body, including in immune function. Its unique blend of anxiolytic, antidepressant, and neurotrophic properties, coupled with its role in increasing the expression of BDNF (brain-derived neurotrophic factor), makes it a promising candidate for a range of cognitive and psychological conditions.
The administration of Selank is often through subcutaneous injections or nasal spray, allowing for ease of use and rapid absorption. 
This peptide therapy has been approved in Russia and is being studied worldwide for its potential to help people treat not only anxiety and depression, but also to boost cognitive enhancement and neuroprotection.
Pros:
Regulates important neurotransmitters to boost cognitive performance
Improves memory and learning abilities
Regulates BDNF expression
Pronounced anxiolytic that reduces anxiety symptoms and stress
Cons:
This peptide drug is not yet approved by the FDA
More clinical studies are needed to fully understand the long-term impact of this drug’s administration
Mechanism of Action
Selank is a synthetic peptide derivative that exhibits a unique and complex mechanism of action that contributes to its various therapeutic effects, particularly in the realm of cognitive enhancement and anxiety management.
Here is a breakdown of the mechanism of action for peptide anxiolytic Selank.
Interaction with Neurotransmitter Systems:
GABAergic System: Selank is known to influence the gamma-aminobutyric acid (GABA) system, the primary inhibitory neurotransmitter system in the brain.(1) This interaction is believed to be central to Selank’s anxiolytic (anxiety-reducing) effects. Unlike benzodiazepines, which also target the GABA system and GABA receptors, Selank does not lead to dependency or significant sedation.
Serotonergic Activity: Selank modulates serotonin levels, a neurotransmitter associated with mood regulation. This increase in serotonin levels helps in alleviating symptoms of depression and anxiety, contributing to an overall improvement in emotional well-being.
Dopaminergic Influence: There’s evidence suggesting that the effect of Selank also affects dopamine, a neurotransmitter linked with motivation, pleasure, and reward. This might contribute to its cognitive-enhancing effects.(2)
Memory and Learning: By influencing neurotransmitter systems and enhancing neurotrophic factors like BDNF, Selank can potentially improve cognitive functions such as memory and learning.

Modulation of Peptide Systems:
Peptide Therapy Parallel: As a peptide, the action of Selank interacts with various endogenous peptide systems in the body. It mimics the effects of tuftsin, a natural immunomodulatory peptide, thereby potentially influencing immune function and boosting metabolic rate from within. This action provides medical support for a healthy human body.
Impact on Brain-Derived Neurotrophic Factor (BDNF): Selank has been observed to regulate the expression of BDNF, a protein that plays a crucial role in nerve cell growth and plasticity. This aspect of Selank’s action is particularly relevant in neuroprotection and cognitive enhancement.(3)

Anti-inflammatory and Immunomodulatory Properties:
Inflammation Reduction: Selank exhibits anti-inflammatory properties, which can be beneficial in conditions where chronic inflammation is a factor.
Immune System Modulation: Its influence on the immune system is not just limited to its tuftsin-like activity. Selank can modulate immune responses, which may be beneficial in reducing the immune-related components of stress and anxiety.
Anxiolytic Effects Without Sedation:
Unique Anxiolytic Profile: Unlike many traditional anxiolytics, Selank provides anxiety relief without causing significant sedation or cognitive impairment. This makes it a favorable option for individuals seeking to manage anxiety while maintaining mental clarity and alertness.
Nootropic Benefits of Selank
Selank has garnered attention in the field of cognitive enhancement for its nootropic benefits. 
The research and development of Selank at the Institute of Molecular Genetics and Research Institute of Pharmacology involved extensive studies to understand its pharmacological profile, safety, and efficacy.(4)
These findings suggest that Selank stimulates various neurotransmitter systems and enhances brain function.
Below is an overview of the nootropic benefits of Selank.
1. Improvement in Memory and Learning
Selank has been shown in animal studies to enhance cognitive processes, particularly in memory and learning.(5) This is partly due to its impact on neurotransmitter systems like dopamine and serotonin, which play crucial roles in cognitive functions.
2. Enhancement of Mental Clarity and Focus
Users of Selank often report improved mental clarity and focus. This is attributed to its modulating effects on brain chemistry, which aids in better concentration and attention.(6)
3. Anxiety Reduction
While primarily known for its anxiolytic properties, Selank’s ability to reduce anxiety contributes to its nootropic effects. Lower anxiety levels lead to better mental performance and reduced mental fatigue.(7)
4. Mood Stabilization
By influencing the serotonin system, Selank treatment helps stabilize mood, which is beneficial for cognitive tasks. A stable mood aids in maintaining consistent performance in mental activities.
5. Stress Reduction
Selank’s ability to mitigate stress impacts cognitive function positively. Chronic stress can impair cognitive abilities, so reducing stress can lead to improved mental performance.(8)
6. Neuroprotective Properties
Selank has shown potential neuroprotective effects, which could be vital in protecting the brain from various forms of cognitive decline and enhancing overall brain health.
7. Enhanced Neuroplasticity
The peptide is known to influence neurotrophic factors like BDNF, which play a critical role in neuroplasticity – the brain’s ability to reorganize and form new neural connections. Improved neuroplasticity is associated with better learning and memory capabilities.(9)
8. Reduced Mental Fatigue
Selank helps alleviate symptoms of mental fatigue, making it easier to perform cognitive tasks for extended periods.
9. Improved Attention Span
Selank’s impact on neurotransmitter systems can lead to significant changes such as improved attention span and focus, aiding in tasks that require prolonged mental effort.
10. Aid to Manage Cognitive Disorders
While more research is needed on this functional medicine, Selank shows promise as a potential adjunct therapy in cognitive disorders due to its neuroprotective and cognitive-enhancing properties.